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商品信息

產(chǎn)品英文名稱	Anti-α-Tubulin Monoclonal Antibody (3G5)
產(chǎn)品中文名稱	α-Tubulin單克隆抗體（3G5）
別名	TUBA1A; Tubulin alpha-1A chain; Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain

商品屬性

克隆類型	單克隆
檢測類型	IF,IP,WB,IHC-P
反應(yīng)性	小鼠,人,大鼠
宿主	小鼠
免疫原	重組蛋白
產(chǎn)品形式	液體形式
基因ID	7846/10376
目標(biāo)條帶分子量	52
蛋白序列鏈接	/uniprot/Q71U36
存儲緩沖液	PBS緩沖液（pH 7.4），含有0.5%BSA（穩(wěn)定劑），0.02％（防腐劑）和50％甘油。
保存建議	自發(fā)貨之日起，-20°C可穩(wěn)定保存1年。為限度的避免損失，請在打開管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復(fù)凍融。
運輸條件	冰袋運輸（藍(lán)冰）
警告	本文列出的產(chǎn)品僅供研究使用，不適用于人類或臨床診斷。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何或許可證。對于使用本產(chǎn)品可能發(fā)生的侵權(quán)或其他違規(guī)行為，我們不承擔(dān)任何責(zé)任。

附加信息

背景

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. TUBA1A encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that TUBA1A expression is predominantly found in morphologically differentiated neurologic cells. TUBA1A is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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