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BPS Bioscience Inc.
中級(jí)會(huì)員 | 第3年

13829799985

當(dāng)前位置:BPS Bioscience Inc.>>Inhibitors / Activators>> 27736-2AT13387

AT13387

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產(chǎn)品型號(hào)27736-2

品       牌BPS Bioscience

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●Purchase●DescriptionAT13387
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Description

AT13387, discovered by a high-throughput x-ray craystallography fragment-based platform, is a non-geldanamycin inhibitor of heat shock proterin 90 (HPS90), a molecule chaperone regulating signal transduction pathways for cell growth and survival. It has high affinity for binding HSP90 (Kd = 0.5nM) and exhibited an in vitro cytotoxicity showing a median EC50 value of 41 nM. The antitumor activity of AT13387 against solid tumor and leukemia models is similar to alvespimycin.

Synonyms
(2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone

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